The problem of the survival of the Croatian health system due to the increasing number of departures of Croatian health professionals is getting bigger and more serious every year. Namely, the exodus of doctors, but also of all other healthcare professionals, has been increasing since the Republic of Croatia's entry into the European Union. How does human resource management affect the departure of doctors from the Republic of Croatia? What are the causes of dissatisfaction among doctors in the Croatian healthcare system? What are the most important reasons for the migration of Croatian doctors? Detecting the problems that doctors face on a daily basis, as well as information on how many of them are thinking about leaving and what could possibly keep them in the Republic of Croatia, can greatly contribute to the creation of a roadmap for future steps with well-organized management of human resources in healthcare. This kind of comprehensive research will give an insight into the real situation and real problems, and it is also possible to influence the creation of tools suitable for successfully solving the detected problems and finding a quality strategy for retaining medical personnel in the domicile health system. The aim and purpose of this work were to analyze and systematize theories of migration and create a conceptual framework for a better understanding of the reasons for migration, then to investigate the perceptions of Croatian doctors about the reasons for migration and satisfaction at the workplace, as well as to formulate a scientifically based basis for the formation of future human resource management strategies in healthcare. The empirical part of the work was conducted using the survey method, for which a questionnaire was created as a data collection instrument. The method of in-depth interviews served as a corrective method.